Both are in superb form and have yet to drop a set at this year's championship. Britain's Murray, the number one seed, will face 28th ranked Fabio Fognini from Italy while Spaniard Nadal will go up against Russian Karen Khachanov, ranked 30.
Roger Federer came out wearing a cream sweater while he opened the title defence at Wimbledon on Monday.
Norma Godinho has just about caught her breath after all the action at SW19 on Super Sunday. Here are Norma's memorable moments from this year's Wimbledon.
IMAGES from Day 10 of the Wimbledon 2022 Championships at the All England Lawn Tennis and Croquet Club in London, on Wednesday.
Andy Murray's tearful defeat in his first Wimbledon final proved the catalyst for the Scot's golden summer, according to Roger Federer, the man who crushed Murray's hopes that day in July.
Images from Day 4 of the Wimbledon tennis championships played in London, on Wednesday.
Wimbledon finally dragged itself into the 21st century as it announced equal prize money for women.
Andy Murray joined Emma Raducanu through the exit door after a four-set defeat by John Isner.
Murray was slightly vexed by a question at the post-match news conference that suggested the fans' loyalties were more divided than if he were playing anyone but Federer.
Six-time champion Roger Federer produced a vintage display to beat defending champion Novak Djokovic 6-3, 3-6, 6-4, 6-3 in the Wimbledon semi-final on Friday.
Rewarding as it was for Rafael Nadal to become the only player to win the same Grand Slam 12 times by chalking up his dozen at last month's French Open, the Spaniard arrived at Wimbledon this year like a man on a mission. In the end, however, it became mission impossible as he lost to inspired Roger Federer in Friday's blockbuster semi-final.
Top seed Novak Djokovic set up a blockbuster Wimbledon final against Nick Kyrgios after recovering from a torrid start to overwhelm Britain's Cameron Norrie 2-6, 6-3, 6-2, 6-4 on Friday.
Old rivalries will be renewed on and off the court in the men's Wimbledon final on Sunday when Roger Federer, bidding for a record eighth title, takes on top seed Novak Djokovic.
Jamie Murray's hopes of making up for brother Andy's Wimbledon semi-final defeat by Roger Federer ended in disappointment when he and partner John Peers lost the men's doubles final to Jean-Julien Rojer and Horia Tecau on Saturday.
World No 5 Roger Federer's possible records aside, it is the first time since 2003 that the semis have featured four men outside the top four in the world rankings.
The All England Club's medical rooms were overflowing as the third day of Wimbledon resembled a casualty ward with Rafa Nadal's conqueror Steve Darcis one of five players to withdraw injured before mid-afternoon on Wednesday.
The world number one opens his defence against Alexander Bublik, a lucky loser ranked 134, on Centre Court in front of his home fans on Monday.
Images from Day 6 of Wimbledon at the All England Lawn Tennis and Croquet Club in London, on Saturday.
Andy Murray once again fills the prime time viewing slot on Centre Court late on Saturday, while five-time women's champion Venus Williams will have revenge on her mind against Carla Suarez Navarro.
Indian cricket legend Sachin Tendulkar and his wife Anjali Tendulkar watch the men's semi-final match between Roger Federer and Novak Djokovic from the Royal Box on Centre Court at Wimbledon.
Federer begins the pursuit of a record eighth Wimbledon title and a record 85th match win at the grass court major; Djokovic hoping to curb dismal slide
Images from Day 10 of Wimbledon at the All England Lawn Tennis and Croquet Club in London, on Thursday.
'If I was running for a drop shot, I was limping there more than running.'
It will be 'Mother's Day' on Wimbledon's Centre Court on Monday when Serena Williams takes on fellow mum Evgeniya Rodina for a place in the quarter-finals of the grasscourt major.
An inspired Halep took full advantage of an error-strewn display by seven-time champion Williams to become the first Romanian to win the Wimbledon title.
Here is a quick glance of all the highs and lows from Nadal's stupendous career:
India's Leander Paes and Zimbabwe's Cara Black strolled on Centre Court after Rafael Nadal had won the men's singles and took their second Grand Slam title of the year after the Australian Open with a 6-4, 7-6 victory against South Africa's Wesley Moodie and Lisa Raymond from the Unites States.
Wimbledon was invaded by thousands of flying ants on Wednesday, causing much annoyance to players, officials and ticket holders alike - but there was little anyone could do to drive out the pests.
The 10th seeds and French Open champions lost 7-6(4), 4-6, 5-7 to the unseeded Finnish-British combo in exactly two hours on centre court.
As tradition demands the Serb will open play on Centre Court on Monday as defending men's champion but rather than a gentle loosener the 28-year-old faces a real danger in the form of Germany's Philipp Kohlschreiber, the world number 33.
Andre Agassi and wife Steffi Graf during played a mixed doubles match against Tim Henman and Kim Clijsters at an exhibition event to unveil the new retractable roof over Centre Court at Wimbledon in London, on Sunday.
The sweet spot of Andy Murray's racket was put through its paces as he signed of his first week at Wimbledon by stylishly dispatching Spain's Tommy Robredo 6-2, 6-4, 7-5 to move into the last 16 on Friday.
PHOTOS from day seven of the Wimbledon championships at the All England Lawn Tennis in London on Tuesday.
Djokovic beats Wawrinka just before closing time
Wildcard Harriet Dart was probably surprised, therefore, when she looked up to see the Duchess of Cambridge sat in the front row of seats on Court 14 on Tuesday.
Friday's showdown will be the 40th meeting between the duo with Rafael Nadal leading 24-15 and 10-3 in Grand Slams.
Former champions Venus Williams and Andy Murray were named in Wimbledon's initial list of wildcards
Images from the Wimbledon matches played on Monday.
Roger Federer is one match away from a record 15th Grand Slam title after easily beating Germany's Tommy Haas in the semi-finals.
Images from Day 4 at the Wimbledon Championships, on Thursday.
